admission@niet.co.in
+91-8010-500-700
Experience
0.3 Year
Dr. Dolly Sharma, Ex Lead Scientist and Trainer in Drug Discovery and Cheminformatics, is an experienced researcher specializing in biorelevant small molecules targeting cancer. Her work includes G-quadruplex targeting, tumor glycolysis, metal complexes, DNA origami, and the synthesis of nanoparticles for therapeutic applications. She has expertise in target- and fragment-based drug discovery, biological activity assays, and cancer cell metabolism. With three registered patents and over 10 high-impact publications in international journals, she has made significant contributions to drug design and nanodevices. Her extensive patent experience highlights her innovation in cancer treatment through advanced synthesis techniques and novel drug development strategies.
Education
Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, U.P. India
Biotechnology, School of Biotechnology, Gautam Buddha University, Greater Noida, U.P. India
Biotechnology, School of Biotechnology, Gautam Buddha University, Greater Noida, U.P. India
Research
The research focuses on target and fragment-based drug design and discovery aimed at treating various cancers, including pancreatic, breast, and head & neck cancers, by targeting the cellular energetics of cancer cells as opposed to healthy cells. It involves the design and synthesis of small drug-like molecules that inhibit enzymes or proteins overexpressed in cancers, inflammation, and malaria. Additionally, the synthesis of small molecules as G-quadruplex binders is explored to target cancer, bacterial diseases, and drug resistance. The work also includes basic research into the microwave-assisted synthesis and green chemistry of small molecules, as well as the identification of plant-based natural products with potential therapeutic applications.
Key Publications
- Dolly Sharma, Mamta Singh, Reshma Rani. Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics, Seminars in Cancer Biology https://doi.org/10.1016/j.semcancer.2022.11.007 (Impact Factor- 14.5)
- Mamta Singh, Dolly Sharma, Manoj Garg, Atul Kumar, Ankur Baliyan, Vinit Kumar, Reshma Rani. Current understanding of biological interactions and processing of DNA origami nanostructures: Role of machine learning and implications in drug delivery, Biotechnology Advances Volume 61, December 2022, 108052. DOI: https://doi.org/10.1016/j.biotechadv.2022.108052 (Impact Factor- 17.8)
- Mamta Singh, Julieta Afonso, Dolly Sharma, Rajat Gupta, Vivek Kumar, Reshma Rani, Fátima Baltazar, Vinit Kumar. Targeting monocarboxylate transporters (MCTs) in cancer: How close are we to the clinics? Seminars in Cancer Biology, Vol 90, 2023, Pages 1-14, https://doi.org/10.1016/j.semcancer.2023.01.007. (Impact Factor- 14.5)
- Dolly Sharma, Mamta Singh, Jayadev Joshi, Dr Manoj Garg, Vidhi Chaudhary, Daniel Blankenberg, Sudhir Chandna, Vinit Kumar and Reshma Rani. Design and Synthesis of Thiazole Scaffold-Based Small Molecules as Anticancer Agents Targeting the Human Lactate Dehydrogenase A Enzyme. ACS Omega https://doi.org/10.1021/acsomega.2c07569 (Impact Factor- 4.1)
- Dolly Sharma, Mamta Singh, Sweta Verma, Manoj Garg, Andrea Altieri, Alexander V. Kurkin, Vinit Kumar, Reshma Rani. Targeting Virus-Induced Reprogrammed Cell Metabolism via Glycolytic inhibitors: an effective therapeutic approach against SARS-CoV-2, Mini- Reviews in Medicinal Chemistry, doi: 10.2174/1389557522666220616112042 (Impact Factor- 3.5)
- Dolly Sharma, Mamta Singh, Vivek Kumar, Rajat Gupta, Vinit Kumar, Reshma Rani. Intervention on Lactate: An effective approach in cancer therapeutics, Advances in Cancer Biology–Metastasis, 2022,100058, ISSN 2667-3940, doi: https://doi.org/10.1016/j.adcanc.2022.100058 (Impact Factor- 2)
Professional Distinctions
Awarded with the best oral presentation entitled, “Design, synthesis and anticancer activity evaluation of pseudo-pyrimidine derivatives” in International Conference on Recent Advances in Applied Sciences (ICRAAS-2022) organized by the Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, India in association with World Researchers Association (WRA) during March 23-24, 2022
Patent
- 3 (Under examination)
